Antimetabolites and the Disruption of DNA Synthesis
Antimetabolites are a class of chemotherapy drugs that masquerade as the building blocks of DNA and RNA (purines and pyrimidines). Once the cancer cell incorporates these "false" molecules into its metabolic pathways, the synthesis of new genetic material is halted, or the resulting DNA is non-functional. These drugs are S-phase specific, meaning they are most effective during the active...
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